Is it Safe to Combine Methylprednisolone and Alcohol?

Methylprednisolone can cause stomach pain and ulcers.
Aspirin use should also be avoided when taking methylprednisolone.
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  • Written By: Jodee Redmond
  • Edited By: Bronwyn Harris
  • Last Modified Date: 28 October 2014
  • Copyright Protected:
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Methylprednisolone and alcohol should not be used together. This medication acts on the user's stomach and intestinal tract to make it more sensitive to irritants being ingested, including alcohol. A person taking this steroid will find that he or she is more likely to develop stomach ulcers, and may need to avoid using aspirin-based products while taking it to avoid irritating this part of the body.

This type of medication is a steroid which may be prescribed to treat medical conditions causing inflammation in the body, such as arthritis. It can also be used to treat concerns, including psoriasis, lupus and ulcerative colitis. Patients who have been diagnosed with certain types of breathing disorders may benefit from taking methylprednisolone.

It’s important for people who have been prescribed methylprednisolone to take the medication as prescribed. The pharmacist will explain how often it should be taken. Since this drug is likely to cause stomach upset, it may be helpful to take it with milk or food.

Using methylprednisolone and alcohol is not the only caution patients who have been prescribed this medication need to keep in mind. People who are allergic to aspirin or eggs should not take methylprednisolone, for example. An individual who has a fungal infection anywhere but on the skin is also cautioned against taking this medication.


Aspirin can irritate the stomach and since this medication increases the risk of stomach ulcers, a patient should discuss his or her options for using over the counter products for pain relief before taking it. The combination of methylprednisolone and alcohol along with an irritant like aspirin can lead to damage in the patient’s stomach and intestinal tract.

Other side effects which are not related to taking methylprednisolone along with alcohol use include restlessness, anxiety and depression. A person who is taking the medication and starts experiencing these symptoms should let his or her doctor know right away. Stopping the medication all at once is not recommended, since it can trigger some side effects, including weight loss, head and body aches, as well as difficulty staying awake.

If the issue of methylprednisolone and alcohol doesn’t come up at the doctor’s visit, a person who is being prescribed the medication should be prepared to do so. A person who has an addiction to alcohol may need to use a different medication to avoid the types of health issues which may result from the interaction. Consulting a physician for a pharmacist for professional advice is advised.


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Discuss this Article

Post 5

@Mor - Methylprednisolone is a pretty serious drug, actually, so you need to be extremely careful while taking it. If you don't take the whole course, for example, it can actually kill you, because there's a kind of tapering off they do in dosage at the end in case you have a bad reaction.

My grandmother was on it for arthritis for a while, so they made sure the whole family knew what the dangers were so we could watch out for her.

Post 4

It's really important to make sure you know what the dangers of the medication you're on are. I've noticed they don't always volunteer all of them at the doctor's or the pharmacy, so I always try to ask and then I usually double check on Wikipedia to make sure.

They usually have it listed on there, with all the foods you can't have with it and why, and what side effects to expect.

I've had bad reactions with drugs before and I prefer to be on them as little as possible, so I always try to follow the instructions to the letter.

Post 3

@literally45-- I work at the ER and I remember once we had someone come in due to methylprednisolone and alcohol interaction. His blood pressure was high and he was having heart palpitations as well. So it's really not a good idea to mix these two.

Methylprednisolone interacts with a lot of stuff. Most medications do interact with alcohol and should generally be avoided but methylprednisolone can even interact with grapefruit.

Methylprednisolone makes the digestive system so sensitive that even foods and non-alcoholic drinks that would normally be fine can cause negative symptoms. It's best to avoid acidic and spicy foods while on this medicine, as well as smoking and drinking.

Post 2

@literally45-- Absolutely not.

Alcohol doesn't just irritate the stomach and counteract with methylprednisolone, but it also makes this steroid's side effects worse.

What this means is that while you might not have experienced much side effects until now, you can experience them if you combine this steroid with alcohol. It's an unnecessary risk. You should just avoid alcohol until your treatment is over.

Post 1

I'm on methylprednisolone and it hasn't irritated my stomach or made it more sensitive so far. Does this mean that I might be able to tolerate some alcohol while on this medication?

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