Is it Safe to Take Phenylephrine in Pregnancy?

Phenylephrine may cause birth defects if taken during the first trimester.
Taking phenylephrine in pregnancy for a short period of time is less likely to cause problems than long term use, especially if the mother is in the second or third trimester.
Article Details
  • Written By: Mary McMahon
  • Edited By: Shereen Skola
  • Last Modified Date: 10 October 2014
  • Copyright Protected:
    2003-2014
    Conjecture Corporation
  • Print this Article

Limited research is available on the safety of phenylephrine in pregnancy, but available data suggests this medication poses relatively low risks to pregnant mothers. The drug is classified by the Food and Drug Administration (FDA) in the United States in Category C, which means that some birth defects in animals have been observed and studies on humans are limited. The benefits of taking the medication may outweigh the risks, particularly after the first trimester, which tends to to be the danger zone with fetal exposure and birth defects. Patients with questions or concerns can talk to a doctor or other qualified medical professional about any special risks that may contraindicate the use of phenylephrine while pregnant.

This drug is a decongestant patients may take during coughs and colds to feel more comfortable. Studies indicate that it does not increase the risk of pregnancy loss. Birth defects associated with phenylephrine in pregnancy appear to be rare, but there is a small increased risk of a condition called gastroschisis, an abdominal wall defect. The defect can cause the contents of the abdomen to protrude and will require surgical treatment.

Ad

Fetuses exposed to phenylephrine in the first trimester are slightly more likely to develop gastroschisis than the general population. If the mother smokes, this risk can increase. The risks are associated with the vasconstriction caused by phenylephrine, which can limit the flow of blood to the fetus. Women are also slightly more at risk of hypertension in pregnancy when using this drug for extended periods of time.

Patients with heavy congestion have a number of tactics they can use to address it before turning to decongestants like phenylephrine in pregnancy. Some women find it helpful to cut out dairy products and certain foods that can increase mucus production and make congestion more uncomfortable. Saline rinses of the nose can be helpful as well. If these measures do not risk, a doctor may recommend phenylephrine because the benefits outweigh the risks.

Taking phenylephrine in pregnancy for a short period of time is less likely to cause problems than long term use, especially if the mother is in the second or third trimester. Women who find themselves needing phenylephrine for more than three or four days should consult a doctor. They may have an underlying health problem that is causing congestion and could require medical attention. The drug appears to be safe for use in breastfeeding at the recommended dose, although some breastfeeding infants become irritable or restless while their mothers take the medication.

Ad

More from Wisegeek

You might also Like

Discuss this Article

dfoster85
Post 2

@ElizaBennett - You make a nice point, which is basically that it's important to consider not only the effects of the medicine on your unborn baby, but also the effect of your condition!

For instance, I had a bad cough in late pregnancy, around thirty weeks. My doctor was concerned that this could cause preterm labor or premature rupture of membranes. So he put me on a codeine cough syrup. He said that while taking narcotics during pregnancy is certainly not ideal, it was a heck of a lot better than being born at thirty weeks. And because I was far from my due date, there was certainly plenty of time for the drugs to clear baby's system before delivery--that's really important with narcotics, because otherwise baby goes into withdrawal.

ElizaBennett
Post 1

A friend of mine was actually advised by a home birth midwife to take a decongestant! And home birth midwives are pretty notorious for being anti-medication; they don't like you to take a lot of Tums, for instance, while most OBs will let you eat all you want to of them.

But here's the thing--my friend had a terrible cold. And bad colds are more likely to turn into sinus infections if you do not get any relief. The midwife didn't want my friend to wind up on antibiotics, so she told her to go ahead and take something. (She actually recommended pseudeophedrine. That's the one that you now have to go to the pharmacy counter to buy. Phenylephrine wasn't used as much any more but it is becoming more common because it can be included in medicines that are sold right from the shelves.)

Post your comments

Post Anonymously

Login

username
password
forgot password?

Register

username
password
confirm
email