What Are Iron Injections?

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  • Written By: Cindy Quarters
  • Edited By: S. Pike
  • Last Modified Date: 16 July 2014
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Iron deficiency is the most common cause of anemia in the United States, according to the National Anemia Action Council. In many cases, the problem can be corrected by changes in diet or by taking oral iron supplements. In some cases, though, the best way to correct iron deficiency is through the use of iron injections. Iron injections can be given either intramuscularly, into the buttocks, or intravenously (IV). Both types must be administered by trained medical personnel.

Oral iron supplements are often used to increase iron levels, but oral iron tablets can cause uncomfortable side effects such as upset stomach and constipation. For people who need additional iron but are unable to get enough orally, the doctor may suggest iron injections. These injections can be given either in a muscle or intravenously, and they are an efficient way to get iron-rich fluid directly into the body. Iron injections help the body to build red blood cells more quickly than other forms of iron, and they are also helpful for people who are not able to absorb iron due to medication they are taking or for other reasons. This is the best form of supplementation for anyone who has a serious problem with anemia.


There are three main types of iron injections. Which one a patient is given is determined by his or her medical problems and physical condition. The most commonly used type of iron injection is iron dextran, which has the advantage of being able to be given as a single large dose. Iron dextran is available in both intramuscular and intravenous formulations.

For people who cannot tolerate iron dextran, ferumoxytol is a newer form of injectable iron, given in intravenous form only. This iron is administered in two doses, three to eight days apart. It does not take as long to administer ferumoxytol as it does to administer iron dextran, and it is generally well-tolerated and effective.

The third type of iron injection is referred to as a carbohydrate injection, because it includes a form of sugar along with the iron suspension. The two solutions that fall into this category are iron sucrose and ferric gluconate. Both are given in a series of multiple small doses, and they are administered in intravenous form only. These do not cause any allergic reactions in patients but require many trips to the doctor for the administration of the IVs.

Allergic reactions are possible with iron dextran and ferumoxytol iron injections, including anaphylaxis, which can be life-threatening. Other possible side effects of all three types can include nausea, dizziness, flushing, muscle pain, joint pain, headache, fever, chills, a drop in blood pressure, and inflammation or pain at the injection site. The severity of the symptoms varies from person to person. Despite the possible drawbacks, for those who need them, iron injections can be beneficial, even life-saving, and well worth having to put up with some discomfort.


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