I was looking into the Nerium claims. I have researched a bit and found that harmful topical applications are from raw materials, are rare and generally an allergic reaction.
I'd like to point out that botulism is an extremely deadly neurotoxin in extremely small doses, but people have Botox injections regularly.
I am not a doctor. You should always consult your physician before using a product that you are questioning the safety of.
However, I have found no evidence to support that the harmful glycocides have absorbed into the bloodstream from a topical application. After looking into it a bit, I would feel more confident applying Nerium-AD than I would having Botox injections.