@ysmina-- I think they're both effective. The reason I'm using vitamin E vaginal suppositories is because I have a cyst in my breast and I'm not allowed to take estrogen. But vitamin E suppositories work fine for menopause related vaginal dryness. The one I use also has natural oils in it and it has pretty much treated the dryness.
I did experience headaches when I first started using it but like the article said, it went away with use.