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What is a Polymorphonuclear Leukocyte?

Jillian O Keeffe
Jillian O Keeffe

A polymorphonuclear leukocyte is a type of white blood cell, with "leuko" meaning "white" and "cyte" meaning "cell." The polymorphonuclear name derives from the common appearance of the lobed nucleus of the cell, which appears to be many nuclei stuck together. A polymorphonuclear leukocyte is also known as a granulocyte because of the grainy nature of the cell's cytoplasm.

The polymorphonuclear leukocyte group is divided into three types. These are basophils, neutrophils and eosinophils. These types of cells are named for their staining properties when the cells are stained so they can easily be seen under a microscope. The basophils are stained by basophilic stains, and the eosinophils are stained easily by a chemical called eosin. The neutrophils do not take up either acidic or basic stains particularly well and are, therefore, identifiable by their mild staining by both types.

The polymorphonuclear leukocyte group is divided into three types, including eosinophils, which multiply in response to allergic reactions.
The polymorphonuclear leukocyte group is divided into three types, including eosinophils, which multiply in response to allergic reactions.

Polymorphonuclear leukocytes, which make up around 70 percent of all white blood cells, are produced in the bone marrow as part of the immune system. The cells that manufacture the cells are called myeloblasts. The polymorphonuclear leukocytes pass through stages of growth when they are called myelocytes and metamyelocytes before becoming leukocytes. Cells in these early stages of growth do not respond the same way to staining as more advanced cells do, and can also be recognized by differences in nuclear structure.

Neutrophils, a type of polymorphonuclear leukocyte, move to an affected area of the body when the immune system begins the inflammation process to combat infections.
Neutrophils, a type of polymorphonuclear leukocyte, move to an affected area of the body when the immune system begins the inflammation process to combat infections.

Neutrophils make up about 60 percent of white blood cells and are roughly twice the size of a red blood cell. Neutrophils contain lysosomal enzymes in their cell granules. Lysosomal enzymes are substances that break down bacterial cells. When the immune system begins the process of inflammation to combat infections, the neutrophils move from the bloodstream to the affected area. They congregate there and recognize bacteria by the antibodies the immune system attaches to the bacteria as a marker for destruction.

A diagram showing different types of leukocytes, or white blood cells, including the three types of  polymorphonuclear leukocytes.
A diagram showing different types of leukocytes, or white blood cells, including the three types of polymorphonuclear leukocytes.

Eosinophils are less common than neutrophils, and make up less than 6 percent of the white blood cells found in the bloodstream. Their function is not well known, but they do multiply in response to parasite infection or allergic reactions. Basophils are even less common than eosinophils, making up less than 1 percent of white blood cells. Their function is to trigger the process of inflammation in a similar role to tissue mast cells. Basophils, eosinophils and neutrophils are all about the same size.

Polymorphonuclear leukocyte cells may be seen under a microscope.
Polymorphonuclear leukocyte cells may be seen under a microscope.

Despite the name polymorphonuclear leukocyte, the cells do not necessarily contain the multi-lobed nucleus at all times. Immature neutrophils have a nucleus in the shape of a band, and eosinophils and basophils may also have band-shaped nuclei. Eosinophils may also have only two lobes on their nucleus.

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    • The polymorphonuclear leukocyte group is divided into three types, including eosinophils, which multiply in response to allergic reactions.
      By: Evgenia Tiplyashina
      The polymorphonuclear leukocyte group is divided into three types, including eosinophils, which multiply in response to allergic reactions.
    • Neutrophils, a type of polymorphonuclear leukocyte, move to an affected area of the body when the immune system begins the inflammation process to combat infections.
      By: Tatyana Gladskih
      Neutrophils, a type of polymorphonuclear leukocyte, move to an affected area of the body when the immune system begins the inflammation process to combat infections.
    • A diagram showing different types of leukocytes, or white blood cells, including the three types of  polymorphonuclear leukocytes.
      By: apple1
      A diagram showing different types of leukocytes, or white blood cells, including the three types of polymorphonuclear leukocytes.
    • Polymorphonuclear leukocyte cells may be seen under a microscope.
      By: Natis
      Polymorphonuclear leukocyte cells may be seen under a microscope.
    • Leukocytes are an important component of blood and a key player in the body's immune system.
      By: designua
      Leukocytes are an important component of blood and a key player in the body's immune system.