Early symptoms are headache, fever, fatigue and a rash that occurs on most, but not all infected tick bites. The rash develops after about three days.
The disease can spread throughout the blood within days. Joints and stiffness in the neck can develop, interfering with sleep. Later in the disease progression increasingly troublesome symptoms can happen include heart troubles. Increasing neurological problems like loss of muscle tone in the face called facial palsy can develop. A very dangerous infection called meningitis, an infection of the fluid around the brain and spinal cord, has been known to occur. Encephalitis and altered mental status have been known to develop in some cases.
Continued spreading of the disease without care can lead to severe permanent issues.