I've heard that if an NSAID like aspirin were introduced today, it would be considered a controlled substance and we'd all need a prescription to get it. I don't know about that, but I will say that two Aleve tablets work just about as well as any regular strength prescription painkiller I've ever taken.
There are other types of OTC pain pills that will help lessen the effects of a headache or ease muscle pain, but I find that an NSAID like Aleve will take care of actual inflammation better than anything else. I don't understand some of the chemistry mentioned in the article, but I feel like naproxen sodium gets at an illness differently than other pain relievers like Tylenol. If I have a fever, I'll reach for an NSAID first.