@bythewell - I actually think there's more of an issue with liver damage if you are taking huge amounts of ibuprofen. I've heard of people taking several pills to cure their hangover, which is a terrible idea.
Not only have you stressed your liver with the alcohol, but you add the effects of the medicine on top of that. You would also be irritating any stomach ulcers with alcohol, then adding something that makes you bleed more easily. Not a great combination.
Ibuprofen can also dilate blood vessels, so I can imagine a huge dose having an effect on internal bleeding for this reason as well.
In other words, use it with caution, particularly if you are using it as a hangover cure.